Dr. Rajkumar Sunil Singh

Designation: Associate Professor

Specialization: Organic Chemistry

Contact: 8414803784

Email: rksunil3000 [AT] gmail.com; rksunilsingh [AT] manipuruniv.ac.in

Post-Doctoral: University of California, Los Angeles, USA (2004-08; Bio-organic Chemistry)

Faculty Details Faculty List

Faculty Profile

1. Name : Dr. Rajkumar Sunil Singh

2. Designation : Associate Professor

3. Department : Chemistry

4. Specialization : Organic Chemistry

5. Phone : 8414803784

6. Email : rksunil3000 [AT] gmail.com; rksunilsingh [AT] manipuruniv.ac.in

7. Education :

1. B. Sc.: Jadavpur University, Kolkata (1993-96; Chemistry (Honours))

2. M. Sc.: Jadavpur University, Kolkata (1996-98; Organic Chemistry)

3. Ph. D.: CSIR–Indian Institute of Chemical Technology, Hyderabad (1999-2004; Bio-organic Chemistry)

4. Post-Doctoral: University of California, Los Angeles, USA (2004-08; Bio-organic Chemistry)

8. Fellowship/Award: CSIR-JRF (1999-2001); CSIR-SRF (2001-2004)

9. Work Experience:

1. Research Scientist: ClinInvent Research Pvt Ltd., New Delhi (2008-2012)

2. Assistant Professor: North–Eastern Hill University, Shillong (2012-2023)

3. Associate Professor: Manipur University, Imphal (2023–present)

10. Research Areas:

1. Small-molecule gelators and their applications:  Molecular gels are an interesting class of soft materials consisting of fibrous networked structures and a liquid component trapped within these structures. We are interested in the rational design and synthesis of small-molecule gelators and their applications. We are particularly interested in applying these gelators for visual detection of various analytes.

2. Non-traditional amphiphiles and their applications:  Another area of interest is in the design, synthesis and self-assembly of amphiphiles with unconventional structures.

 

11. Research Projects:

1. Title: “Development of siRNA nano carriers using click chemistry and gene silencing studies of a cancer gene target” (DST; 2009-12; Rs 19.5 lakhs; Principal Investigator).

2. Title: “Inhibiting the inhibitors of apoptosis using siRNAs: Developing apoptosis inducers as potential anticancer agents” (DBT; 2010-13; Rs. 32.95 lakhs; Principal Investigator).

 

12. Ph.D Awarded:

1. Mr. Wangkhem Paikhomba Singh

Thesis title: “Synthesis and Functional Properties of Novel Low Molecular Weight Gelating Molecules” (Awarded – December 2022)

13. Publications:

1. Wangkhem Paikhomba Singh, Laishram Robindro Singh, Rajkumar Sunil Singh*. “Gelation–based visual detection of fluoride ion: Strategic use of silyl protection–deprotection chemistry”. Journal of Molecular Liquids, 2022, 119536 (IF = 6.633).

2. Rajkumar Sunil Singh*. “Langmuir and Langmuir–Blodgett films of aromatic amphiphiles”. Soft Materials, 2022, 20, 57–98 (IF = 2.429).

3. Wangkhem Paikhomba Singh, Sanjeev Bhandari, Rajkumar Sunil Singh*. “Organogelators derived from the bisphenol A scaffold”. New Journal of Chemistry, 2021, 45, 15655–15666 (IF = 3.591).

4. Wangkhem Paikhomba Singh, Rajkumar Sunil Singh*. “A new triphenylsilyl-containing gelator for visual sensing of fluoride ion”. Materials Chemistry and Physics, 2020, 241, 122351 (IF = 4.094).

5. Wangkhem Paikhomba Singh, Utpal Koch, Rajkumar Sunil Singh*. “Gelation of ionic liquids by small-molecule gelators and their applications”. Soft Materials, 2020, 18, 386–410 (IF = 2.429).

6. Wangkhem Paikhomba Singh, Rajkumar Sunil Singh*. “Gelation-based visual detection of analytes”. Soft Materials, 2019, 17, 93–118 (IF = 2.429).

7. Wangkhem Paikhomba Singh, Rajkumar Sunil Singh*. “A new class of organogelators based on triphenylmethyl derivatives of primary alcohols: Hydrophobic interactions alone can mediate gelation”. Beilstein Journal of Organic Chemistry, 2017, 13, 138–149 (IF = 2.88).

8. Rajkumar Sunil Singh, Christine Goncalves, Pierre Sandrin, Chantal Pichon, Patrick Midoux*, Arabinda Chaudhuri*. “On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal Protonation: A chemical biology investigation”. Chemistry & Biology, 2004, 11, 713–23 (IF = 8.116).

9. Bharat Kumar Majeti^#, Rajkumar Sunil Singh^#, Sudheer Kumar Yadav, Surendar Reddy Bathula, Sistla Ramakrishna, Prakash Vamanrao Diwan, Surkara Sakunthala Madhavendra, Arabinda Chaudhuri*. “Enhanced intravenous transgene expression in mouse lung using cyclic-head cationic lipids”. Chemistry & Biology, 2004, 11, 427–37 (^# equal contributing authors) (IF = 8.116).

10. Rajkumar Sunil Singh, Arabinda Chaudhuri*. “Single additional methylene group in the head-group region imparts high gene transfer efficacy to a transfection-incompetent cationic lipid”. FEBS Letters, 2004, 556, 86–90 (IF = 4.124).

11. Valluripalli Vinod Kumar, Rajkumar Sunil Singh, Arabinda Chaudhuri*. “Cationic transfection lipids in gene therapy: Successes, setbacks, challenges and promises”. Current Medicinal Chemistry, 2003, 10, 1297–1306 (IF = 4.53).

12. Rajkumar Sunil Singh, Koushik Mukherjee, Rajkumar Banerjee, Arabinda Chaudhuri*, Samik Kumar Hait, Satya Priya Moulik, Yerramsetti Ramadas, Amash Vijayalakshmi, Nalam Madhusudhana Rao*. “Anchor dependency for non-glycerol based cationic lipofectins: Mixed bag of regular and anomalous transfection profiles”. Chemistry – A European Journal, 2002, 8, 900–908 (IF = 5.236).

13. Saumitra Sengupta*, Subir Kumar Sadhukhan, Rajkumar Sunil Singh, Nilashish Pal “Synthesis of dendritic stilbenoid compounds: Heck reaction for periphery and the core”. Tetrahedron Letters, 2002, 43, 1117–1121 (IF = 2.415).

14. Saumitra Sengupta*, Subir Kumar Sadhukhan, Rajkumar Sunil Singh. “A palladium catalyzed synthesis of wheel and axle hydrocarbons: Strategic use of tetraphenylmethane stoppers”. Indian J Chem SecB, 2002, 41B, 642–644 (IF = 0.592).

15. Saumitra Sengupta*, Subir Kumar Sadhukhan, Rajkumar Sunil Singh. “Heck reactions of arenediazonium salts with phenyl vinyl sulfones: A new synthesis of styryl sulfones”. Indian J Chem SecB, 2001, 40B, 997–999 (IF = 0.592).
     

14. Oral/Poster Presentations/Invited Lectures:

1. “Molecular gels”, Rajkumar Sunil Singh, Resource Person, Refresher Course in Chemical Sciences, organized by UGC HRDC, Manipur University, Imphal, Manipur, 17^th – 30^th November 2022.

2. “Synthesis and Langmuir monolayer studies of a new class of triphenylmethyl group-containing bulge amphiphile”, Sanjeev Bhandari, Wangkhem P. Singh, Mrityunjoy Mahato, Rajkumar Sunil Singh, XIII Biennial National Conference of Physics Academy of North East (PANE), 2022, 8^th – 10^th November 2022, organized by Department of Physics, Manipur University, Imphal, Manipur.

3. “Langmuir monolayer studies of a new class of triphenylmethyl group- containing bulge amphiphiles” Utpal Koch, Wangkhem P. Singh, Sanjeev Bhandari, Mrityunjoy Mahato, Rajkumar Sunil Singh, 1^st International Conference on Frontiers in Chemical Sciences, organized by Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore, 4^th – 5^th , 2020.

4. “Triphenylmethyl and triphenylsilyl derivatives of simple primary alcohols: From molecular gels to visual fluoride sensor”, Rajkumar Sunil Singh, 19^th NATCOSEB Conference, Amity University, Kolkata, 18^th – 20^th October 2019 organized by Indian Society for Surface Science and Technology & Amity University, Kolkata.

5. “Triphenylmethyl derivatives of primary alcohols as a new class of organogelators”. Wangkhem Paikhomba Singh, Rajkumar Sunil Singh, International Conference on Sophisticated Instruments in Modern Research (30^th June – 1^st July, 2017) jointly organized by Central Instruments Facility-IIT Guwahati, Central Instruments Facility-IASST, SAIC-Tezpur University, SAIF-Gauhati University and SAIF-NEHU.

6. “Molecular gels from triphenylmethyl derivatives of simple primary alcohols”. Rajkumar Sunil Singh, “National Conference on Recent Advances in Nanoscience and Nanotechnology” (8^th – 9^th Sept, 2016) organized by Dept of Nanotechnology, North-Eastern Hill University, Shillong-793022.

7. “Triphenylmethyl derivatives of simple primary alcohols are good organogelators”. Wangkhem Paikhomba Singh, Rajkumar Sunil Singh, National Symposium on Emerging Trends in Chemistry (ETC-2016), organized by Department of Chemistry, NEHU, Shillong during 28^th – 29^th March, 2016.

8. “Is nuclear structure altered in breast cancer cells?” (2008, June 25 – 28) Han Htun, Rajkumar Sunil Singh, and Wendy J. Dixon. Era of Hope, Dept of Defence, Breast Cancer Research Program, Baltimore, MD, USA. 

9. “Direct visualization of glucocorticoid receptor and RNA polymerase II supports formation of chromatin loops in the interphase nucleus of living mammalian cells.” (2006) Han Htun, Rajkumar Sunil Singh, Wendy J. Dixon, Toni Lee, C. Lee, C. Liang, Y. K Lee. Proceedings of the 46^th Annual Meeting of American Society for Cell Biology held at San Diego, USA, December 9 – 13, 2006.

10. “Endosomal protonation of pH-sensitive cationic transfection lipids may not be a crucial mechanistic event in liposomal gene delivery”. (2004) Rajkumar Sunil Singh, Christine Goncalves, Pierre Sandrin, Chantal Pichon, Patrick Midoux and Arabinda Chaudhuri. Proceedings of the 8^th ADNAT (Association for the Promotion of DNA Fingerprinting and other DNA Technologies) Symposium on Comparative and Functional Genomics held at the Centre for Cellular and Molecular Biology, Hyderabad, India during February 23 – 24, 2004.

11. “Even one additional methylene group in the head-group region can impart high gene transfer properties to a transfection-incompetent cationic lipid”. (2004) Rajkumar Sunil Singh and Arabinda Chaudhuri. Proceedings of the 8^th ADNAT (Association for the Promotion of DNA Fingerprinting and other DNA Technologies) Symposium on Comparative and Functional Genomics held at the Centre for Cellular and Molecular Biology, Hyderabad, India during February 23 – 24, 2004.

12. “Anchor dependency for non-glycerol based cationic lipofectins: Mixed bag of regular and anomalous transfection profiles.” (2001) Rajkumar Sunil Singh, Koushik Mukherjee, Rajkumar Banerjee, Arabinda Chaudhuri, Yerramsetti Ramadas, Amash Vijayalakshmi and Nalam Madhusudhana Rao. Proceedings of the 7^th National Bioorganic Symposium held at the Guru Nanak Dev University, Amritsar, India during November 9 – 10, 2001.