Designation: Professor & Head
Specialization: Organic Chemistry
Email: ok_mukherjee [AT] yahoo.co.in, omsingh [AT] manipuruniv.ac.in
Name: Dr.Okram Mukherjee Singh
Designation: Professor & Head
E-mail: (a) ok_mukherjee[AT]yahoo.co.in (b) omsingh[AT]manipuruniv.ac.in
Area of specialization: Organic Chemistry
Current interest: Synthesis of bioactive heterocycles and natural products
Qualification: M.Sc. Ph.D.
Academic Qualification (Graduate onwards)
1. Summer Research Fellowship award by Indian Academy of Sciences, Bangalore to work for 2 months in University of Hyderabad 1997.
2. MANIPUR SCIENCE &TECHNOLOGY YOUNG SCIENTIST AWARD 1998.
3. DST BOYSCAST FELLOWSHIP 2005.
4. COMMONWEALTH ACADEMIC STAFF FELLOWSHIP 2012
1.University of Utah, USA in the group of Prof. Peter J. Stang, 2005-2006(For conducting advanced research in self assembly and suparamolecular chemistry).
2. University of Manchester, UK in the group of Prof. E. J. Thomas, 2012(For conducting advanced research on the synthesis of natural products).
3. DST international travel grant award for visiting Vienna, Austria to participate in the Tetrahedron Symposium in 2013.
4. DST international travel grant award for visiting University Regensbertg, Germany to participate in the 17th International Society of Heterocyclic Chemistry (ISHC) Congress in 2017
GFP Chromophores from L-Phenylalanine: Synthesis, Photophysical and Thermal Properties. Thokchom Prasanta Singh, Thokchom Jeeta Devi, Ningthoujam Premananda Singh, Okram Mukherjee Singh. ChemistrySelect, 2018, 3. 6596-6600.
Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4–SiO2 under solventfree conditions. Leimajam Vartima Chanu, Thokchom Prasanta Singh, Laishram Ronibala Devi, Okram Mukherjee Singh, Green Chemistry Letters and Reviews, 2018, 11, 352-360. DOI: 10.1080/17518253.2018.15109.
Recent Progress in Biological Activities of Indole and Indole Alkaloids, T. Prasanta Singh and O. Mukherjee Singh, Mini Reviews in Medicinal Chemistry, 2018,18(1), 9 – 25. DOI: 10.2174/1389557517666170807123201
Synthesis of Functionalized Benzo[f]2H-Chromenes and Evaluation of Their Antimicrobial Activities. I. Harimala Chanu, L. Ronibala Devi, N. Khumanthemc, N. Irabanta Singh, D. Kumar, O. Mukherjee Singh, Russian Journal of Bioorganic Chemistry, 2017, 43, 177–185.DOI: 10.1134/S1068162017020054
One pot synthesis of 1-substituted tetrahydro-β-carbolines by Bischler–Napieralski cyclization, T. Prasanta Singh and O. Mukherjee Singh, Journal of Chemical Sciences, 2016, 128, 565-572.
Novel Synthesis of Tryptamine Derived 4?Hydroxy?4?arylthiazolidine?2?thiones and 4?Arylthiazole?2(3H)?thiones by Multicomponent Reactions. N. Sushuma Devi, S. Joychandra Singh, K. Mahiya, L. Ronibala Devi, O. Mukherjee Singh, H. Choi, S.-G. Lee, Bulletin of the Korean Chemical Society, 2016, 37, 1472-1477.
Synthesis and biological evaluation of novel carbazolyl glyoxamides as anticancer and antibacterial agents, V. Reddy P O, M. P. Tantak, R.Valdez, R. Prakash Singh, O. Mukherjee Singh, R. Sadana and D. Kumar RSC Adv., 2016,6, 9379-9386.
Facile Synthesis of Octahydroxanthenes by One-Pot Reaction under Solvent-Free Condition. L. R. Devi, L. V. Chanu, I. H. Chanu, O. M. Singh, Asian J. Chem. 2016, 28,1528-1530. DOI: 10.14233/ajchem.2016.19746
GC-MS Analysis of Phytocomponents and Antifungal Activities of Zanthoxylum acanthopodium DC. Collected from Manipur, India. O. Zenita Devi, K. Sreenivasa Rao, A. Bidalia, R.Wangkheirakpam, O. Mukherjee Singh, European Journal of Medicinal Plants, 2015,10, 1-9.
Silica–ZnCl2: An Efficient and Reusable Solid Catalyst for One Pot Synthesis of 5-Methyl Mercaptothiocarbonyl-4-aryl-3- dihydropyrimidin-2(1H)-ones Under Solvent-Free Conditions. L. Ronibala Devi, L. Vartima Chanu, H. Choi, D. Lee, O. Mukherjee Singh, S.-G. Lee. Bulletin of the Korean Chemical Society, 2015, 36, 2915–2919
Regioselective synthesis of polyaza pyrimidines and polyaza pyrazoles under one-pot multicomponent reaction conditions. O. Mukherjee Singh, L. Ronibala Devi, K. Bum Lim, S.-G. Lee, J. Heterocyclic Chem., 2014, 51, 1340-1344. ( DOI 10.1002/jhet.1781) ISSN: 1943-5193.
Indium(III) Chloride mediated Michael addition of indoles to ketene S,S-Acetals: Synthesis of Bis- and Tris-indolylketones. T. Prasanta Singh, Ruhima Khan, Young Ri Noh, Sang-Gyeong Lee, Okram Mukherjee Singh, Bull. Korean Chem. Soc. 2014, 35, 2950-2954. (http://dx.doi.org/10.5012/bkcs.2014.35.10).
One-Pot Synthesis of 1H-Naphtho[2,1-b]pyran Derivatives under Solvent-Free Conditions. K. Ameeta Devi, L. Gellina Chanu, I. Harimala Chanu, O. Mukherjee Singh, Letters in Organic Chemistry, 2014, 11, 743-747.
Synthesis of imidazo[1,2-a]pyridines and pyrido[1,2-a]pyrimidines in water and their SNAr cyclizations. L. Gellina Chanu, Th. Prasanta Singh, Yong Ju Jang,Yong-Jin Yoon, Sang-Gyeong Lee, Okram Mukherjee Singh, Bull. Korean Chem. Soc. 2014, 35, 994-1000. (http://dx.doi.org/10.5012/bkcs.2014.35.4.994).
Indium/TFA-catalyzed synthesis of tetracyclic indole alkaloids, via a tandem cycloannulation of β-oxodithioester with tryptamine. T. Prasanta Singh, S.Bhattacharya, O. Mukherjee Singh, Organic Letters, 2013, 15, 1974-1977. (DOI: 10.1021/ol400644m)
Facile route to highly functionalized 2H-chromene-2-thiones via ring annulations of β-oxodithioesters catalyzed by AlCl3 under solvent free conditions. N. Sushuma Devi, S. Joychandra Singh, L. Ronibala Devi, O. Mukherjee Singh. Tetrahedron Lett, 2013, 54, 183.
An efficient transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent free conditions. N. Sushuma Devi, S. Joychandra Singh, O. Mukherjee Singh,
Tetrahedron Lett, 2013, 54, 1432.
Stannous chloride as a versatile catalyst in organic synthesis. O. Mukherjee Singh and L. Ronibala Devi, Mini-Reviews in Organic Chemistry, 2013, 10, 84-96
Synthesis of 2,6-diamino substituted α-oxoketene S,N-acetals: Crystal structure and
hydrogen bonding interactions. Okram Mukherjee Singh , Laishram Ronibala Devi and Neeladri Das Journal of Chemical Sciences, 2013, 15, 1103-1107.( ISSN: 0974-3626)
Synthesis of chromene-2-thiones and in vitro evaluation of their antifungal and
antibacterial activities. N. Sushuma Devi, T. Prasanta Singh, N. Khumanthem and Okram Mukherjee Singh, Indian Journal of Chemistry, 2013, 52B, 1224-1231.( ISSN: 0376-4699)
Datura stramonium: An overview of its phytochemistry and pharmacognosy. L. Rajeep
Singh, O.Mukherjee Singh, Research J. Pharmacognosy and Phytochemistry, 2013,5,143-148.(ISSN 0975- 2331).
An efficient one-pot multicomponent synthesis of 2,3-dihydro-3-alkyl/aryl-2-thioxoquinazolin-4(1H)-ones under solvent-free conditions. N. Sushuma Devi, S. Joychandra Singh, O. Mukherjee Singh, Synlett, 2012,23,2111.
Facile synthesis of spiro-fused heterocycles by multicomponent reactions under solvent-free reactions. L.Ronibala Devi, Okram Mukherjee Singh Indian Journal of Chemistry, Sect.B, 2012, 51B, 1426.
A First Synthesis and Physical Properties of Asymmetric Anthracenes-Thiophenes Bridged with Ethylene. Min Ji Hwang, Ji Hee Park, Eun Bin Jeong, Il Kang, Dong Hoon Lee,Chan Eon Park, O. M. Singh, HoJune Choi, Yoon-Hi Kim,Yong Jin Yoon, Soon-Ki Kwon, Sang-Gyeong Lee, Bull. Korean Chem. Soc. 2012, 33, 3810 – 3816. (ISSN: 0253-2964).
Intramolecular cyclocondensation of α-oxoketene N,N-, N,S- and N,O-acetals : synthesis of novel pyrido[1,2-a]pyrimidinium tetrafluoroborates. O. Mukherjee Singh, L. Ronibala Devi, T. Prasanta Singh, H. Ila, Arkivoc. 2011, (ii), 297-309. (ISSN: 1551-7004)
Facile Synthesis of 3-Thioxo-3H-benzo[f]chromen-2-yl methanone and 3H-Benzo[f ]chromene-3-one Under Solvent Free Condition. Okram Mukherjee Singh, Nepram Sushuma Devi, Laishram Ronibala Devi, Ki Bum Lim, Yong Jin Yoon and Sang-Geyong Lee, Bull. Korean Chem. Soc. 2011, 32, 175-178. (ISSN: 0253-2964)
Stannous Chloride Promoted Synthesis of S-Allyl-N-Aryl Dithiocarbamates Under Solvent-Free Conditions. Okram Mukherjee Singh, Nepram Sushuma Devi, Synthetic Communications. 2011, 41, 516–522. (ISSN: 0039-7911)
Adhatoda vasica Nees: Phytochemical and Pharmacological profile. Thokchom Prasanta Singh, Okram Mukherjee Singh, Huidrom Birkumar Singh, The Natural Product Journal. 2011, 1, 29-39. (ISSN: 2210-3155)
Phytochemistry and pharmacological profile of Zanthoxylum armatum DC. – An overview. Okram Mukherjee Singh, Thokchom Prasanta Singh, Indian Journal of Natural Products and resources, 2011, 1, 275–285. (ISSN: 0976–0504)
Organic reactions in microwave conditions Journal of Applied Chemistry, 2011, 2, 35-37. (ISSN: 0976-7355)
Phytochemistry of Solanum Xanthocarpum: an amazing traditional healer. Okram Mukherjee Singh, Thokchom Prasanta Singh, Journal of Scientific &Industrial Research (CSIR). 2010, 69,732-740. (ISSN: 0022-4456)
Friedel-crafts reactions of Indole under Solvent-free Conditions. Okram Mukherjee Singh, Thokchom Prasanta Singh, Journal of Applied Chemistry (ISST). 2010, 1,7-11. (ISSN: 0976-7355)
Cupric Chloride Catalysed Synthesis of 5-Methyl mercaptothiocarbonyl-4aryl-3,4-dihydropyrimidin-2(1H)-ones ones under Solvent-free Conditions and their microboial activities. Okram Mukherjee Singh, Nepram Sushuma Devi, Laishram Ronibala Devi, Nonibala Khumanthem. International Journal of Drug Design and Discovery 2010, 1, 258–264. (ISSN: 0975-8275)
Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities. O. Mukherjee Singh, N. Sushuma Devi, D. Singh Thokchom, G. Jitendra Sharma, European Journal of Medicinal Chemistry 2010, 45, 2250–2257.
Regioselective Synthesis of Heterocyclic Ketene N,N-, N,O- and N,S-Acetals in Aqueous Medium. Okram Mukherjee Singh, L. Gellina Chanu, Sang Hun Jang, Sang-Gyeong Lee, Bull. Korean Chem. Soc. 2010, 31, 859-862. (ISSN: 0253-2964)
Synthesis and Characterization of Highly Conjugated Cyclopenta[def]phenanthrene-Based Polymers. Okram Mukherjee Singh, Sang Hun Jang, Truong Ba Tai, Ji Hee Park, Hee Jeong Jeong, Eun Jeong Chun, Yun-Hi Kim, and Sang-Gyeong Lee, Yong Jin Yoon, Soon Ki Kwon. Macromolecular Research, 2010,18,185-191. (ISSN: 1598-5032)
Metal Catalyzed Reactions: Synthesis of Bioactive Compounds and C-C Bond Forming Reactions. Okram Mukherjee Singh, Th. Prasanta Singh, N. Sushuma Devi, L. Gellina Chanu. Organic Chemistry: An Indian Journal. 2009, 5, 195-198. (ISSN: 0974-7516)
Application of β-Oxodithioesters in Domino and Multicomponent Reactions: Facile route to Dihydropyrimidines and Coumarins. O. Mukherjee Singh, N. Sushuma Devi, J. Org. Chem. 2009, 74, 3141-3144.
Cupric Chloride Promoted Regioselective C-Allylation of Enaminones. O. Mukherjee Singh, S. Joychandra Singh, Tetrahedron Letters, 2008, 49, 3991-3994.
Synthesis and in-vitro evaluation of the antifungal activities of dihydropyrimidinones. O. Mukherjee Singh, S. Joychandra Singh, M. Babita Devi, L. Nalini Devi, N. Irabanta Singh, S.-G. Lee, Bioorg. Med. Chem. Lett. 2008, 18, 6462-6467.
Cupric Chloride Promoted Regioselective C-Allylation of Enaminones. Okram Mukherjee Singh, Sarangthem Joychandra Singh, Tetrahedron Letters, 2008, 49, 3991-3994.( doi:10.1016/j.tetlet.2008.04.093)
Isolation and Characterization of Triterpene Lactones from Phlogacanthus Thyrsiflorus Nees (Acanthaceae). O. Mukherjee Singh, W. Marjit Singh & K. Subharani Devi, Natural Products: An Indian Journal, 2008, 4, 71-73.
SnCl2-Catalyzed Synthesis of Dihydropyrimidinones under Solvent-free Conditions. Okram M. Singh, M. Lokeshwar Singh & S. Joychandra Singh, Heterocyclic Communications, 2007, 13, 277-282. (ISSN: 0793-0283)
Synthesis of Amino Substituted Pyrazoles. Okram Mukherjee Singh, Mohammad Farooque Ahmad, Sarangthem Joychandra Singh and Sang-Gyeong Lee, Journal of Chemical Research, 2007, No.4, 229–232.( ISSN: 1747-5198)
A New Zn / TiCl4 / LiAlH4–Mediated Approach for 2-Aryl or Alkylsubstituted-Benzothiophenes via Intramolecular Cyclization. Okram Mukherjee Singh, Hyung Jae Jeong, Sung Chul Shin, Yong-Jin Yoon, Sang-Gyeong Lee, Synlett, 2007, 9, 1407-1410. (ISSN: 0936-5214)
Isolation of Steroidal Glycosides from Solanum xanthocarpum and Studies on their Antifungal Activities. Okram M. Singh, K. Subharani, N. I. Singh, N. Babita Devi & Nevidita L. Natural Product Research, 2007, 21, 585–590.
Reaction of Lithioamines with Alkyl Halides: A Convenient Direct Synthesis of N-Alkylaminopyridines. Okram Mukherjee Singh, S. Joychandra Singh, Su Nam Kim, and Sang-Gyeong Lee, Bull. Korean Chem. Soc. 2007, 28, 115-117. (ISSN: 0253-2964)
Metathesis Catalysts: Historical Perspective, Recent developments and Practical applications. Okram Mukherjee Singh, Journal of Scientific & Industrial Research (CSIR), 2006, 65, 956-965. (ISSN: 0022-4456
A facile one-pot synthetic method for 1,2,4-triazoles and 1,3-disubstitued thioureas. Okram Mukherjee Singh, Sarangthem Joychandra Singh. Journal of Chemical Research, 2006, 3, 483-485.
Facile Synthesis of Enantiopure Chiral Molecular Rectangles Exhibiting Induced Circular Dichroism. N. Das, O. M. Singh, A. Ghosh & P. J. Stang, Organic Letters, 2006, 8, 1701-1704.
A facile synthesis of pyrrolo[1,2-a]imidazoles and pyrrolo[1,2-a]pyrimidines. Okram Mukherjee Singh, M. F. Ahmed, Dinesh, H. Indian Journal of Heterocyclic Chemistry, 2005, 15, 87-88. (ISSN: 0971-1627)
Report of ACS National Meeting & Expositions. Okram Mukherjee Singh, Current Science, 2005, 89,1658-1659. (ISSN: 0011-3891)
Cyclocondensation of cyanoketene dithioacetal with 2-aminopyridine: Synthesis of pyrido [1, 2-a]pyrimidines. Okram Mukherjee Singh, Mohd Farooque Ahmed, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2004, 43B, 1561-1564. (ISSN: 0376-4699)
A Facile Access to 2-Methylthio/Alkoxy/Amino-3-acylimidazo[1,2-a]pyridines Based on Cupric Chloride Promoted Oxidative Ring Closure of α-Oxoketene N,S-, N,O-, and N,N-Acetals. Okram Mukherjee Singh, Okram Barun, H. Ila & H. Junjappa, Journal of Organic Chemistry, 2000, 65, 1583-1587. (ISSN: 0022-3263)
A facile synthesis of 3-cyclopropyl- and 5-cyclopropylisoxazoles. Okram Mukherjee Singh, H. Ila, & H. Junjappa, Journal of Chemical Research, 1999, 6, 398-399.(ISSN: 1747-5198)
Reaction of β-oxodithioesters with propargylamine: a facile entry to novel 2-(acylalkylidene)-5-(methylene)thiazolidines M. Chandrasekharam, O. Mukherjee Singh, Okram Barun, H. Ila & H. Junjappa Synthetic Communications, 1998, 28, 3073-3079. (ISSN: 0039-7911)
Synthesis of novel 3-cyano-4-methylthio-6-(arylcyclopropyl)-3-(1H)-pyridones and 5(3)-methylthio-3(5)-(arylcyclopropyl)pyrazoles Indian Journal of Chemistry, Section B: 1997, 36B, 1056-1058 Indian Journal of Chemistry, Section B: 1997, 36B, 1056-1058
Reaction of α -bis(methylthio)methylene cyclopropyl ketones with guanidine: synthesis of 2-amino-4-alkoxy-6-(arylcyclopropyl)pyrimidines Indian Journal of Chemistry, Section B: 1997, 36B, 1123-1125. (ISSN: 0376-4699)
Reaction of lithioamino anions with α-oxoketene dithioketals: an improved and a new general method for the synthesis of α-oxoketene S,N- and N,N-ketals Journal of the Chemical Society, Perkin Transactions 1: (Org. Biomol.Chem.), 1997, 23, 3561-3565. (ISSN: 1477-0520)
A new general route to 1,2-diarylethylenes,1,4-diarylbutadienes and 1,6-diarylhexatrienes through cycloaromatization of β-oxodithioacetals. Synthesis, 1992, 11, 1075-1077. (ISSN: 0039-7881)
Application of silica-based heterogeneous catalysis for the synthesis of bioactive heterocycles as Book Chapter in Heterogeneous Catalysis. CRC Press (Taylor & Francis), K. L. Ameta and Andrea Penoni eds, 2014, Chapter 6, 163 -190, ISBN: 978-1-4665-9482-1. Laishram Ronibala Devi and Okram Mukherjee Singh
One pot reaction for the synthesis of coumains under solvent-free condition as Book Chapter Current Topics in Redox Biology, G. J. Sharma & R. N. Sharan eds. McGraw Hill Education (India) Private Limited, New Delhi, 2014, 290-297 (ISBN-13: 978-93-392-1420-3). Laishram Ronibala Devi, Okram Mukherjee Singh
Synthesis and bioactivity of dihydropyrimidines as Book Chapter in Bioactive Heterocycles, Nova Science Publishers Inc, USA, K. L. Ameta, R. P. Pawar & A. J. Domb eds, 2012, Chapter 6, 117-135.(ISBN: 978-1-62257-637-4).
Thokchom Prasanta Singh and Okram Mukherjee Singh
Dithiocarboxylates and related compounds in the synthesis of heterocycles as Book Chapter in Targets in Heterocyclic Systems: Chemistry and Properties 2012, Vol.16, 265-308. Attanasi, Orazio A.; Spinelli, Domenico (Eds.), Royal Society of Chemistry Jointly published with Società Chimica Italiana, ItalySoftcover (also known as softback) version . (ISBN 978-88-86208-52-9). Okram Mukherjee Singh
Some invited lectures delivered in international and national conferences:
Presented a research finding in Monitoring of Ongoing Organic Chemistry EMR Proposal IISER, Bhopal on 26th August, 2018 . Topic: “β-Oxodithioesters in the synthesis of combinatorial library of indole alkaloids and studies on their anticancer activities”
Presented an Invited Talk: “Synthesis and Photophysical Properties of New Indole Derivatives” in an International conference, OrganiX-2018, held in University of Tezpur, Assam, on December 20-21, 2018.
International Society of Heterocyclic Chemistry (ISHC), annual conference at University of Regensberg, Germany, during September 3-8, 2017. International conference on Heterocycles ISHC 26. Talk: “Small Libraries of Bioactive Heterocycles from Dithiocarboxylates”
UGC Sponsored National Seminar, Topic: Emerging trends in Chemical Sciences-2018.Held on 29th January, 2018 at Gauhati University. Invited Talk: “SiO2-HClO4: Synthesis, characterization and applications as reusable heterogeneous catalyst in the synthesis of bioactive heterocycles”
International Conferenmce held on 27-29th March, 2017 at Life Sciences Department ,Manipur University. Topic: International Conference on Natural; resources Management and Technology Trends. Invited Talk
“Indole derivatives and indole based alkaloids from dithiocarboxylates”
Recent Trends in Affordable and Sustainable Drug Discovery and Developments, 22nd Indian Society of Chemists and Biologists Conference (ISCBC-2016), 6-8 February, 2016 at Uka Tarasadia University, Surat, India.
“Synthesis of coumarins and indole derivatives using β-Oxodithioesters” An international symposium on recent advances in chemistry (REACH-2015) in the Department of Chemistry, North-Eastern Hill University, March 03 – 05, 2015.
Presented a poster entitled “A novel threecomponent and tandem synthesis of imidazo[1,2a]pyridines and pyrido[1,2a]pyrimidines in water” 14th Tetrahedron Symposium, 25-28th June, 2013 at Vienna, Austria.
“Diversity Oriented Synthesis: Libraries of Bioactive Heterocycles and Evaluation of Various Biological Activities” in the CRSI East Zone Meeting, International Year of Chemistry 2011 (IYC 2011) Department of Chemistry, University of North Bengal, July 22 – 24, 2011.
“β-Oxodithioesters in Diversity Oriented Synthesis: Designing Combinatorial Libraries of Bioactive Heterocycles” in the National Symposium on “Organometallic Chemistry & Organic Synthesis: Highlights and New Perspectives(OMCOS)”, in the Department of Chemistry, North-Eastern Hill University, March 28 – 29, 2011.
Members of Scientific Associations:
Life Member of Indian Science Congress, India.
Life Member of CRSI, Bangalore, India.
Life Member of Indian Association of Chemists and Biologist (ISCB), CDRI Lucknow, India & Zonal Secretary of North East, ISCB
Life Member of Indian Council of Chemists (ICC), Agra, India
Life Member of Indian Association of Chemistry Teachers (IACT), Mumbai , India.
Annual Member of American Chemical Society (ACS), USA.
Annual Member of International Society of Heterocyclic Chemistry (ISHC), USA
Research Projects (ongoing/completed) during the current year:
DBT, NER Twinning project Title: Extraction of Bioactive Compounds & development of Pesticide Formulations from aromatic Plants available in North Eastern Region No. BT/25414/NER/95/1183/2017
DST Project Title: β-Oxodithioesters in the synthesis of combinatorial library of indole alkaloids and studies on their anticancer activities. No: EMR/2014/000331
CSIR Project, Synthesis of new materials & studies on their applications as organic thin film transistors (OTFT). No. 02(0251)/15/EMR-II dated 26th November 2015.