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Manipur Univ


Prof. Dr. Reena Haobam

Designation: Professor

Specialization: Biochemistry, Neuroscience, Stem cell Biology

Contact:

Email: reena_haobam[AT]rediffmail.com, reena_haobam[AT]manipuruniv.ac.in

M.Sc., Ph.D.

Website: http://manipuruniv.ac.in/faculty/72

Faculty Details Faculty List

Name of the faculty: REENA HAOBAM

Designation: Professor, Department of Biotechnology, Manipur University

E-mail: reena_haobam[AT]rediffmail.com, reena_haobam[AT]manipuruniv.ac.in

Specialization: Biochemistry, Neuroscience, Stem cell Biology

Area of research:

Genomics of drug dependency, Genotyping of MDR-TB and drug metabolism genes, Identification and purification of neuro-protective molecules from plant sources.

Research publications:

  1. Anupama Pandey, Heikrujam Nilkanta Meitei, Bidyarani Devi Konjengbam, Hamidur Rahaman and Reena Haobam. Association of NOS2A Gene Polymorphisms with Susceptibility to Tuberculosis in Manipuri Population of Northeast India. Biochemical Genetics. 2025, Jan 8, PMID: 39776372, https://doi.org/10.1007/s10528-024-11015-w (I.F. 2.1)

 

  1. Aruna Chanu Hijam, Yaiphabi Chanu Tongbram, Pooja Devi Nongthombam, Heikrujam Nilkanta Meitei, Arunkumar Singh Koijam, Yallapa Rajashekar, Reena Haobam. Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals, Neurochemistry International, 180, 105855, 2024. (I.F. 4.4)

 

  1. Aruna Chanu Hijam, Arunkumar Singh Koijam, and Reena Haobam, “Methanol extract of Isodon ternifolius (D. Don) KUDO leaves has antimicrobial and antioxidant activities but no neuroprotective activity”, Int. J. Exp. Res. Rev., 2024, 39: 200-212. (CiteScore- 1.0)

 

  1. Aruna Chanu Hijam, Yaiphabi Chanu Tongbram, Pooja Devi Nongthombam, Heikrujam Nilkanta Meitei, Arunkumar Singh Koijam, Yallapa Rajashekar, Reena Haobam, “Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells”, Journal of Ethnopharmacology, 2024, 330, 118197. (I.F.- 4.8)

 

  1. Pooja Devi Nongthombam and Reena Haobam, “Targeting phosphodiesterase 4 as a potential therapy for Parkinson’s disease: a review”, Molecular Biology Reports, 2024, 51:510. (I.F.- 2.6)

 

  1. Arunkumar Singh Koijam, Kabrambam Dasanta Singh, Bunindro Singh Nameirakpam, Reena Haobam, Yallappa Rajashekar, “Drug addiction and treatment: An epigenetic perspective”, Biomedicine & Pharmacotherapy, 2024, 170, 115951. (I.F.- 6.9)

 

  1. Hamidur Rahaman, Herojit Singh Khundrakpam, Laishram Rajendrakumar Singh, Reena Haobam and Aron B Fisher, “Structural and functional diversity of the Peroxiredoxin 6 enzyme family”. Antioxid Redox Signal, 2024, 40(13-15):759-775.  (I.F.- 5.9)

 

  1. Heikrujam Nilkanta Meitei, Anupama Pandey, Reena Haobam. “Polymorphisms in drug metabolism genes as a risk factor for first‑line anti‑tuberculosis drug‑induced liver injury” Mol Biol Reports, 2023, 50:3:2893-2900. (I.F.- 2.6)

 

  1. Ahanthem D, Thiyam M, Haobam R & Laitonjam WS. “Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-d] pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media.” Indian J of Chem, 2021, 60B:1243-1257. (I.F.- 0.456)

 

  1. Koijam AS, Hijam AC, Singh AS, Jaiswal P, Mukhopadhyay K, Rajamma U & Haobam R. “Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur”, J of Molecular Neuroscience, 2021, 71:122-136. (I.F.-2.8)

 

  1. Koijam AS, Chakraborty B, Mukhopadhyay K, Rajamma U & Haobam R. “A single nucleotide polymorphism in OPRM1 (rs483481) and risk for heroin use disorder”, Journal of Addictive Diseases, 38:2, 214-222, 2020. (I.F-1.6)

 

  1. Singh KA and Haobam R. “Association of DRD2 gene polymorphism with heroin dependence.” Heroin Addict Relat Clin Probl, 21(4): 5-14, 2019. (I.F-0.8)

 

  1. Haobam R, Tripathy D, Kaidery NA and Mohanakumar KP. “Embryonic stem cell derived neuron transplantation recovery in models of parkinsonism in relation to the severity of the disorder in rats.” Rejuvenation Res. 18(2): 173-184, 2015. (I.F-2.2)

 

  1. Tripathy D, Haobam R, Nair R and Mohanakumar KP. “Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats.” PlosOne, 8 (9), e72501, 2013. (I.F-2.9)

 

  1. Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U and Mohanakumar KP. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. 236:136-48, 2013. (I.F-2.9)

 

  1. Madathil KS, Karuppagounder SS, Haobam R, Varghese M, Rajamma U and Mohanakumar KP. Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats. Neurochem Int, 62(5): 674-83, 2013. (I.F-4.4)

 

  1. Haobam R, Sindhu KM, Chandra G, Mohanakumar KP. Swim-test as a function of motor impairment in MPTP model of Parkinson’s disease: a comparative study with two mouse strains. Behav Brain Res, 163(2), 159-167, 2005. (I.F-2.6)

 

  1. Mehta H, Haobam R, Usha R, Mohanakumar KP. Evidence for the involvement of central serotoninergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behav Brain Res, 163(2), 227-236, 2005. (I.F-2.6)

 

Preprints published:

 

  1. Meitei HN, Pandey A, Faruquee H Md, Thokchom M, Athokpam S, Guha H, Das R, Saha S, Kupa R, Kapfo W, Keppen J, Mohapatara AK, Priyadarsini H, Koijam AS, Dasgupta A, Goswami B, Thong A, Meru K, Konyak W, Gupta D, Das A, Khamo V, Huidrom LS, Haobam S, Nanda RK, Haobam R. (2021) Polymorphism of NAT2, PXR, ABCB1, and GSTT1 genes among tuberculosis patients of North Eastern States of India. medRxiv, doi:  https://doi.org/10.1101/2021.06.09.21258600.

 

  1. Faruquee HM, Meitei HN, Pandey A, Pahwa F, Thokchom M, Sonia A, Chaudhary S, Gupta D, Singh HL, Haobam S, Haobam R, Nanda RK. (2021) Urine metabolome of tuberculosis patients receiving intensive phase of treatment show diurnal variations. medRxiv, doi: https://doi.org/10.1101/2021.03.30.21254606.

 

Books chapters published:

  1. Haobam, R., Nongthombam, P.D., Tongbram, Y.C. (2024). Importance of Traditional Medicines in the Treatment of Neurological Diseases. In: Das Talukdar, A., Patra, J.K., Das, G., Nath, D. (eds) Traditional Resources and Tools for Modern Drug Discovery. Interdisciplinary Biotechnological Advances. Springer, Singapore.

 

  1. Hemam Raishowriya Devi and Reena Haobam, “The Effect of Environmental Factors on the DNA Methylation Pattern and Its Impact on Addiction” in Advancement and New Understanding in Medical Science: 10, 53-66, 2024, B.P. International, India & UK.

  2. Chanu HA, Singh KA, Devi NP, Haobam R, “Antimicrobial and Antioxidant Activities of the Crude Extracts of Goniothalamus sesquipedalis (Wall.) Hook. F.&Thomson” in Medicinal Plants- Exploration, Evaluation and Utilization: 1, 116-126, 2019, Pointer Publishers, Jaipur, Rajasthan, India.

  3. Singh KA and Haobam R, “PCR, RFLP and Gel Electrophoresis as Genotyping Tools for Studying SNPs, MicroINDELS and VNTRs” in Trends in Experimental Biology: 2, 95-111, 2016, Excel India Publishers, New Delhi, India.

  4. Haobam R and Mohanakumar KP, ‘Mouse ES cell culture and differentiation to neuronal cells’, A handbook of Neurochemical Techniques for Neuroscientist, 85-88, 2007.

  5. Haobam R, Debasmita T and Mohanakumar KP. ‘Differentiation and characterization of mouse embryonic stem cell derived neuronal cells’, A handbook of Neurobiological Techniques, 9-14, 2008.

Patents:

  • Mohanakumar KP, Chandra G, Haobam R and Selly ML; “Treatment of Brain disorders”, United States Patent Application Publications, Pub. No.: US 2009/0143388 A1, June 4, 2009.

 

Awards and honours:

  • University Gold Medal, M.Sc. (Biochemistry) 2002.

  • University Gold Medal, B.Ed. 2003

  • ICMR-JRF, June 2003

  • UGC-JRF, June 2003

  • DBT-travel award, 2006


 

E-Resource Development:

  • Developed 2 modules and 2 E-contents for the B.Sc (Agri), VI Semester, Couse-Biochemistry, Paper- Soil Science and Agricultural Chemistry (SSAC-363), 2015 under EMRC, Manipur University.

 

  • Developed 8 modules and 8 E-contents for the B.Sc. Biochemistry (NME-ICT-CEC Project) 2018, under the Consortium of Educational Communication, MHRD, Govt. of India.

 

  • Developed 13 modules and 13 E-contents for the MOOCs course on “Immunology”, 2019.

 

  • Course Coordinator for MOOCs “Immunology” (4 credit course) opened in the SWAYAM Portal, MHRD, Government of India in 2019, 2021, 2023 and 2024.

 

 

Projects undertaken:

Sl. No.

Title

Duration

Funding Source

Amount

(in Rupees lakhs)

  1.  

“Analysis of OPRM1 and DAT1 as possible candidate genes for drug addiction: A population-based association study in the Indian population from Manipur”

2012-15

DBT

76.82

(48.47 for PI in MU)

  1.  

Bioactivity guided isolation and purification of neuroprotective molecules from Isodon ternifolius and Tinospora cordifolia.

 

2017-19

IBSD-partnership program

60

(30 for PI in MU)

  1.  

“Evolution and transmission of drug-resistance tuberculosis in Agartala, Kohima and Imphal population”

2018-22

DBT

528.89

(87.99 for PI in MU)

  1.  

“DNA methylation analysis of OPRM1 and DAT1 genes in drug dependent population of Manipur-a population based association study”

2019-2023

ICMR

69.41606


 

Collaborating Institutes:

  • International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi

  • Jawaharlal Nehru Institute of Medical Sciences (JNIMS), Imphal

  • Naga Hospital Authority, Kohima

  • Agartala Government Medical College, Agartala

  • Institute of Bioresources and Sustainable Development (IBSD), Imphal

  • Manovikas Kendra Rehabilitation & Research Institute for the Handicapped (MRIH), Kolkata

 

Membership of Scientific Societies:

  • International Society of Neurochemistry (ISN)

  • Asian Pacific Society of Neurochemistry (APSN)

  • Society of Biological Chemists, India (SBC)

  • Indian Society of Human Genetics (ISHG)

  • Indian Science Congress Association, India (ISCA)

  • Environmental mutagen society of India (EMSI)

 

Ph.D. Scholars:

  1. Koijam Arunkumar Singh (CSIR -NET)- Degree Awarded

  2. Hijam Aruna Chanu (CSIR-NET)- Degree Awarded

  3. Heikrujam Nilkanta Meitei (SLET-NE region, CSIR-NET)- Thesis submitted

  4. Anupama Pandey (Project SRF)

  5. Nongthombam Pooja Devi (UGC-JRF)

  6. Konjengbam Bidyarani Devi (DST-INSPIRED FELLOW)

  7. Hemam Raishworiya Devi (CSIR-JRF)

 

Project Fellows:

 

  • Tongbram Yaiphabi Chanu (Project-JRF, GATE qualified)

 

No. of students that have undergone summer training in the lab: 31